Complex regional pain syndrome (CRPS) is an uncommon form of chronic pain lasting greater than six months, that usually affects one limb (arm, leg, or foot). CRPS typically develops after an injury, cardiovascular event such as a stroke or heart attack, or as a complication of surgery. CRPS is believed to be caused by damage to, or malfunction, of both the peripheral and central nervous system, leading to severe, chronic, neuroinflammation. Women are affected more commonly than men, with a peak incidence occurring in middle age, being rare in children and the elderly.
Fibromyalgia is characterized by widespread musculoskeletal pain typically accompanied by sleep disturbances, chronic fatigue, memory issues, headaches, as well as depression and anxiety. The specific casual factors are still being defined but are thought to involve dysfunction in CNS processing of pain signals. Initiating events can include trauma, infection, surgery, and acute psychological stress, however many cases have no definitive triggering event having symptom severity gradually grow over time. Women appear to be more likely to develop fibromyalgia,as do those with existing osteo and rheumatoid arthritis, and lupus. Given it's tendency to run in families, a genetic mutation is suspected as making certain individuals more susceptible to developing the disorder.
Pancreatic Cancer is a rare cancer, with fewer than 200,000 new cases reported in the US each year. It is among the most serious of all cancer diagnoses, with typically no realistic opportunity for a cure the median survival for untreated advanced pancreatic cancer is only 3 ½ months, with treatment extending that to approximately 8 months. For all stages of pancreatic cancer combined the American Cancer Society describes the one-year survival rate as 20% with the five-year rate having improved only slightly over the past few decades, currently at 7%.
Hailey-Hailey Disease (HHD), also known as chronic benign familial pemphigus, is a rare (prevalence of 1 in 50,000) autosomal dominant genodermatosis characterized by painful vesicles and skin erosions primarily affecting the neck, axillae, and groin regions.
Inflammatory Bowel Disease (IBD) is a term used to describe disorders which involve chronic inflammation of the gastrointestinal tract inclusive of Crohn's disease (CD) and ulcerative colitis (UC). It's etiology is unknown but immune system dysfunction is seen as likely in which an abnormal immune response to a bacterial or viral infection initiates an autoimmune response where the immune system attacks the cells of the digestive tract. It is important to note the importance of diet and stress as aggravating factors in disease severity and triggering of flares.