Background: Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is a common medical condition that limits physical and cognitive functions, with no known effective medical treatment.
Methods: We report on the safety and effectiveness data accumulated in clinical practice when treating ME/CFS with low-dose naltrexone (LDN, 3.0 – 4.5 mg/day). The medical records from 218 patients who received ar diagnosis of ME/CFS and LDN treatment during 2010–2014 were retrospectively analyzed.
Cancer is a major worldwide health problem. Cancer cells express opioid growth factor (OGF) which controls their growth. Naltrexone in low dose (LDN) blocks opioid receptors intermittently and controls the replication of cancer cells. The aim of this study was to investigate the effect of LDN and its chemotherapeutic additive effect on the growth of solid Ehrlich carcinoma in mice with focus on the OGFr and immune responses.
A 64 year old male heating engineer was investigated for a persistent cough and found to have epithelioid mesothelioma with pleural effusion, lung nodules and increased thoracic lymph nodes. He declined standard of care treatment following his own research and he was enrolled in a named patient programme of IMM-101. He was advised to correct his low vitamin D3 level and to start using anti-inflammatories such as aspirin, bromelain and low dose Naltrexone.
Fear of weight gain is a significant obstacle to smoking cessation, preventing some smokers from attempting to quit. Several previous studies of naltrexone yielded promising results for minimization of post-quit weight gain. Given these encouraging findings, we endeavored to test whether minimization of weight gain might translate to better quit outcomes for a population that is particularly concerned about gaining weight upon quitting.
Familial benign pemphigus, or Hailey-Hailey disease (HHD), is a rare (1 in 50,000), benign, autosomal dominant cutaneous disorder that causes a painful rash and blistering commonly occurring in the intertriginous folds. Despite having a good prognosis, there is no cure for HHD and the disease can be quite debilitating to the quality of life.
Psoriasis is a multifactorial skin disease involving abnormal cell proliferation and inflammation; an efficacious topical treatment is yet to be identified. A formulation containing 1% Naltrexone HCl in XemaTop™ base was compounded, characterized and evaluated in vitro as a possible treatment for psoriasis.
To describe the role of opioid antagonist induction in reducing stress response and withdrawal symptoms.
Complexity of naltrexone induction is limiting broader applicability of opioid antagonist-assisted abstinence. The aim of this clinical trial was to assess the stress response to 2 low-dose naltrexone induction protocols under minimal oral sedation.
SAN FRANCISCO — Treatment with low-dose naltrexone resulted in improvements in pain and quality of life scores without serious side effects among patients with neuropathic corneal pain, according to a presenter at the American Academy of Ophthalmology annual meeting.
In this controlled before-after study based on data from the Norwegian Prescription Database, we examine whether starting off-label use of Low Dose Naltrexone (LDN) is followed by changes in the consumption of psychotropic medicines including antiepileptics.
Complex regional pain syndrome (CRPS) is an uncommon form of chronic pain lasting greater than six months, that usually affects one limb (arm, leg, or foot). CRPS typically develops after an injury, cardiovascular event such as a stroke or heart attack, or as a complication of surgery. CRPS is believed to be caused by damage to, or malfunction, of both the peripheral and central nervous system, leading to severe, chronic, neuroinflammation. Women are affected more commonly than men, with a peak incidence occurring in middle age, being rare in children and the elderly.
Fibromyalgia is characterized by widespread musculoskeletal pain typically accompanied by sleep disturbances, chronic fatigue, memory issues, headaches, as well as depression and anxiety. The specific casual factors are still being defined but are thought to involve dysfunction in CNS processing of pain signals. Initiating events can include trauma, infection, surgery, and acute psychological stress, however many cases have no definitive triggering event having symptom severity gradually grow over time. Women appear to be more likely to develop fibromyalgia,as do those with existing osteo and rheumatoid arthritis, and lupus. Given it's tendency to run in families, a genetic mutation is suspected as making certain individuals more susceptible to developing the disorder.
Pancreatic Cancer is a rare cancer, with fewer than 200,000 new cases reported in the US each year. It is among the most serious of all cancer diagnoses, with typically no realistic opportunity for a cure the median survival for untreated advanced pancreatic cancer is only 3 ½ months, with treatment extending that to approximately 8 months. For all stages of pancreatic cancer combined the American Cancer Society describes the one-year survival rate as 20% with the five-year rate having improved only slightly over the past few decades, currently at 7%.
Hailey-Hailey Disease (HHD), also known as chronic benign familial pemphigus, is a rare (prevalence of 1 in 50,000) autosomal dominant genodermatosis characterized by painful vesicles and skin erosions primarily affecting the neck, axillae, and groin regions.
Inflammatory Bowel Disease (IBD) is a term used to describe disorders which involve chronic inflammation of the gastrointestinal tract inclusive of Crohn's disease (CD) and ulcerative colitis (UC). It's etiology is unknown but immune system dysfunction is seen as likely in which an abnormal immune response to a bacterial or viral infection initiates an autoimmune response where the immune system attacks the cells of the digestive tract. It is important to note the importance of diet and stress as aggravating factors in disease severity and triggering of flares.