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Clinical Trials

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Since the late 1970's there have been many trials and studies carried out on Low Dose Naltrexone, LDN. Below you will find a list of published papers which we will update as they become available.

Date Published: 11/2019

Condition: Cancer

Long-term benefit from immune modulation and anti-inflammatory treatment in metastatic mesothelioma

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Date Published: 10/2019

Condition: Skin disorders

In vitro evaluation of Naltrexone HCl 1% Topical Cream in XemaTop™ for psoriasis

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Date Published: 10/2019

Condition: N/A

Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study

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Date Published: 10/2019

Condition: ME/CFS, N/A, Pain

Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

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Date Published: 10/2019

Condition: Opiod use disorder

Dose Escalation of Naltrexone to Reduce Stress Responses Associated With Opioid Antagonist Induction: A Double-blind Randomized Trial

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Date Published: 10/2019

Condition: Pain

Low-Dose Naltrexone Evaluated for Neuropathic Corneal Pain

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Date Published: 10/2019

Condition: Pain

Low-dose naltrexone safe, effective for neuropathic corneal pain

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Date Published: 10/2019

Condition: Pain

A Retrospective Review of Patients Prescribed Low Dose Naltrexone for Chronic Pain at a Single Institution

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Date Published: 10/2019

Condition: Hailey-Hailey, Skin disorders

Hailey-Hailey Disease with Superimposed Eczema Herpeticum Caused by Herpes Simplex Virus Type 2 Infection in a Burn Unit: A Case Report and Literature Review

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Date Published: 10/2019

Condition: Skin disorders

In vitro evaluation of Naltrexone HCl 1% Topical Cream in XemaTop™ for psoriasis

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Date Published: 10/2019

Condition: Depression

Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders

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Date Published: 10/2019

Condition: Depression

Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study

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Date Published: 09/2019

Condition: IBD

Corrigendum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study

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Date Published: 09/2019

Condition: Opiod use disorder, Pain

Safety and tolerability of ALO-02 (oxycodone hydrochloride and sequestered naltrexone hydrochloride) extended-release capsules in older patients: a pooled analysis of two clinical trials

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Date Published: 08/2019

Condition: Hailey-Hailey, Skin disorders

Low-dose naltrexone therapy in benign chronic pemphigus (Hailey-Hailey disease): A case series

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Date Published: 08/2019

Condition: Cancer

Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy

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Date Published: 08/2019

Condition: Alcohol use disorder

Clinically utilized kappa-opioid receptor agonist nalfurafine combined with low-dose naltrexone prevents alcohol relapse-like drinking in male and female mice

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Date Published: 08/2019

Condition: N/A

Opioid antagonists as potential therapeutics for ischemic stroke

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Date Published: 08/2019

Condition: Hailey-Hailey

Low-Dose Naltrexone-Induced Remission in Hailey-Hailey Disease Maintained in Remission with Topical Combination of Ketamine and Diphenhydramine

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Date Published: 08/2019

Condition: Hailey-Hailey

Hailey-Hailey disease treated successfully with naltrexone and magnesium

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Date Published: 08/2019

Condition: N/A

Low-dose naltrexone: a novel adjunctive treatment in symptomatic alopecias?

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Date Published: 08/2019

Condition: Hailey-Hailey

Naltrexone for the Treatment of Darier and Hailey-Hailey Diseases

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Date Published: 06/2019

Condition: Skin disorders

Low-dose naltrexone: a unique treatment for amyopathic dermatomyositis

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Date Published: 06/2019

Condition: Alcohol use disorder

Sex differences in the effect of bupropion and naltrexone combination on alcohol drinking in mice

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Date Published: 06/2019

Condition: Fibromyalgia, Pain

Low Dose Naltrexone Easing Pain from Fibromyalgia and Other Painful Conditions

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Date Published: 06/2019

Condition: N/A

Sjogren's Syndrome: Clinical Benefits of Low-dose Naltrexone Therapy

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Date Published: 05/2019

Condition: Generic

Systemic administration of low-dose naltrexone increases bone mass due to blockade of opioid growth factor receptor signaling in mice osteoblasts

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Date Published: 04/2019

Condition: Pain

Low Dose Naltrexone for Neuropathic Pain Related to an Electrical Burn Injury: A Case Study

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Date Published: 04/2019

Condition: Hailey-Hailey, Skin disorders

Use of low-dose naltrexone in the treatment of severe Hailey-Hailey disease: One case report

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Date Published: 04/2019

Condition: Fibromyalgia

Low-Dose Naltrexone in the Treatment of Fibromyalgia: A Retrospective Analysis

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Date Published: 03/2019

Condition: Hailey-Hailey, Skin disorders

Inexpensive compounding of low dose naltrexone (LDN) with orange juice

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Date Published: 03/2019

Condition: Crohn's Disease

Disease remission after commencing naltrexone in an atypical case of Crohn’s disease complicated by recurrent Clostridium difficile infection

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Date Published: 03/2019

Condition: Fibromyalgia, Pain

Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes

Date Published: 03/2019

Condition: Skin disorders

Low Dose Naltrexone in Dermatology

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Date Published: 03/2019

Condition: Alcohol use disorder

Combination of clinically utilized kappa opioid receptor agonist nalfurafine with low-dose naltrexone reduces excessive alcohol drinking in male and female mice

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Date Published: 03/2019

Condition: Skin disorders

The use of naltrexone in dermatology. Current evidence and future directions

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Date Published: 03/2019

Condition: Pain

Proceedings #47: Low Dose Naltrexone: A Viable Alternative for Long Term Chronic Pain?

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Date Published: 02/2019

Condition: Crohn's Disease, Pain

Treating chronic pain with low dose naltrexone and ultralow dose naltrexone: a review paper

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Date Published: 02/2019

Condition: Pain

Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study

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Date Published: 02/2019

Condition: Depression

Naltrexone and Scopolamine Rapidly Reduce Symptoms of Major Depressive Disorder (MDD): A Double Blinded Randomized Controlled Pilot Study

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Date Published: 02/2019

Condition: Skin disorders

Variable response to low-dose naltrexone in patients with Darier disease: a case series

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Date Published: 01/2019

Condition: N/A

Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis

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Date Published: 01/2019

Condition: Pain

The Use of Low-Dose Naltrexone for Chronic Pain

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Date Published: 01/2019

Condition: Skin disorders

Low-dose Naltrexone: An Alternative Treatment for Erythrodermic Psoriasis

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Date Published: 01/2019

Condition: N/A

Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A)

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Date Published: 12/2018

Condition: Crohn's Disease, Fibromyalgia, Multiple Sclerosis

Intermittent blockade of OGFr and treatment of autoimmune disorders

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Date Published: 12/2018

Condition: Hailey-Hailey, Skin disorders

The Uses of Naltrexone in Dermatological Conditions

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Date Published: 11/2018

Condition: Skin disorders

Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review

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Date Published: 11/2018

Condition: Fibromyalgia, Opiod use disorder, Pain

Clinical utility of the cold pressor test: evaluation of pain patients, treatment of opioid-induced hyperalgesia and fibromyalgia with low dose naltrexone

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Date Published: 10/2018

Condition: Cancer

The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma

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Date Published: 09/2018

Condition: Crohn's Disease, Fibromyalgia, Pain

Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization

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Date Published: 09/2018

Condition: Skin disorders

Successful treatment of dermatomyositis with low-dose naltrexone

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Date Published: 09/2018

Condition: Skin disorders

Treatment of psoriasis vulgaris using low-dose naltrexone

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Date Published: 09/2018

Condition: Substance use disorder

Naltrexone and nalmefene attenuate cocaine place preference in male mice

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Date Published: 09/2018

Condition: N/A

Pharmacokinetic and pharmaceutical properties of a novel buprenorphine/naloxone sublingual tablet for opioid substitution therapy versus conventional buprenorphine/naloxone sublingual tablet in healthy volunteers.

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Date Published: 08/2018

Condition: Hailey-Hailey

Generalized familial benign chronic pemphigus (Hailey-Hailey disease) treated successfully with low-dose naltrexone

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Date Published: 08/2018

Condition: Generic

Compounded Low-dose Naltrexone for the Treatment of Guttate Psoriasis: A Case Report

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Date Published: 07/2018

Condition: Cancer

Low Dose Naltrexone and Lung Cancer: A Case Report and Discussion

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Date Published: 07/2018

Condition: N/A

Scientists get first look at T cell responses in Ebola virus survivors

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Date Published: 07/2018

Condition: N/A

Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats

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Date Published: 06/2018

Condition: Cancer

Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care

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Date Published: 06/2018

Condition: Opiod use disorder

Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial

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Date Published: 06/2018

Condition: Depression, Pain, PTSD

Double-blinded placebo-controlled cross-over pilot trial of naltrexone to treat Gulf War Illness

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Date Published: 06/2018

Condition: Cancer, Crohn's Disease, Multiple Sclerosis

Low-dose naltrexone (LDN): A promising treatment in immune-related diseases and cancer therapy

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Date Published: 06/2018

Condition: Fibromyalgia

The Use and Utility of Low-dose Naltrexone Capsules for Patients with Fibromyalgia

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Date Published: 05/2018

Condition: Autism, Generic

Morphine reduced perceived anger from neutral and implicit emotional expressions

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Date Published: 05/2018

Condition: Crohn's Disease

The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study

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Date Published: 04/2018

Condition: Multiple Sclerosis

McLaughlin leads research on identifying minimally invasive biomarkers for MS

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Date Published: 04/2018

Condition: Crohn's Disease

Low dose naltrexone for induction of remission in Crohn's disease

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Date Published: 03/2018

Condition: Hailey-Hailey

Variable Response to Naltrexone in Patients With Hailey-Hailey Disease

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Date Published: 03/2018

Condition: Ulcerative Colitis

Low dose Naltrexone for induction of remission in inflammatory bowel disease patients

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Date Published: 02/2018

Condition: N/A

Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users: A Preliminary Laboratory Study

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Date Published: 02/2018

Condition: Multiple Sclerosis

Low-dose Naltrexone Changes Levels of Inflammatory Proteins in MS, Study Shows

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Date Published: 01/2018

Condition: N/A

Low-dose naltrexone for the treatment of sarcoidosis

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Date Published: 01/2018

Condition: Multiple Sclerosis

Featured Article: Modulation of the OGF–OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis

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Date Published: 01/2018

Condition: Crohn's Disease, Fibromyalgia, Multiple Sclerosis, Pain

The safety and efficacy of low-dose naltrexone in the management of chronic pain and inflammation in multiple sclerosis, fibromyalgia, Crohn's disease, and other chronic pain disorders

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Date Published: 01/2018

Condition: N/A

Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment

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Date Published: 01/2018

Condition: N/A

Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis

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Date Published: 01/2018

Condition: N/A

Emerging Unconventional Therapies for Alopecia Areata

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Date Published: 12/2017

Condition: N/A

Co-administration of low-dose naltrexone and bupropion reduces alcohol drinking in alcohol-preferring (P) rats

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Date Published: 12/2017

Condition: N/A

The Long-Term Survival of a Patient With Stage IV Renal Cell Carcinoma Following an Integrative Treatment Approach Including the Intravenous α-Lipoic Acid/Low-Dose Naltrexone Protocol

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Date Published: 11/2017

Condition: N/A

Combination therapy for obesity

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Date Published: 11/2017

Condition: N/A

Psychoneuroimmunological approach to gastrointestinal related pain

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Date Published: 11/2017

Condition: Multiple Sclerosis, Pain

Endogenous Opioids in the Etiology and Treatment of Multiple Sclerosis

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Date Published: 11/2017

Condition: Multiple Sclerosis

Ethical Considerations of Patient-Funded Research for Multiple Sclerosis Therapeutics.

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Date Published: 11/2017

Condition: Pain

Neuropathic Corneal Pain: Approaches for Management

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Date Published: 11/2017

Condition: Multiple Sclerosis

Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study

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Date Published: 11/2017

Condition: N/A

Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris

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Date Published: 10/2017

Condition: Hailey-Hailey

Treatment of Hailey-Hailey Disease With Low-Dose Naltrexone

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Date Published: 10/2017

Condition: Hailey-Hailey

Low dose naltrexone: a novel treatment for Hailey-Hailey disease

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Date Published: 09/2017

Condition: Multiple Sclerosis

Featured Article: Serum [Met5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone

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Date Published: 09/2017

Condition: Crohn's Disease, IBD, Ulcerative Colitis

Use of low dose naltrexone and change in use of prescription drugs in patients with inflammatory bowel disease – A drug utilization cohort study based on the Norwegian prescription register

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Date Published: 09/2017

Condition: Generic

Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood.

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Date Published: 09/2017

Condition: Generic

Ultra-Low Doses of Naltrexone Enhance the Antiallodynic Effect of Pregabalin or Gabapentin in Neuropathic Rats.

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Date Published: 09/2017

Condition: Multiple Sclerosis

Low Dose Naltrexone for Treatment of Multiple Sclerosis: A Retrospective Chart Review of Safety and Tolerability

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Date Published: 09/2017

Condition: Cancer

Duration of Opioid Receptor Blockade Determines Biotherapeutic Response

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Date Published: 08/2017

Condition: Hailey-Hailey

Low-Dose Naltrexone Treatment of Familial Benign Pemphigus (Hailey-Hailey Disease)

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Date Published: 08/2017

Condition: Hailey-Hailey

Repurposing Medications—Chicken Manure, Erectile Dysfunction, and Finding the Golden Needle in the Haystack of Absurdity

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Date Published: 08/2017

Condition: N/A

Successful Treatment of Adult-Onset Dermatitis Herpetiformis with Low Dose Naltrexone

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Date Published: 08/2017

Condition: Multiple Sclerosis

Serum [Met5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone

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