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Dose Escalation of Naltrexone to Reduce Stress Responses Associated With Opioid Antagonist Induction: A Double-blind Randomized Trial



To describe the role of opioid antagonist induction in reducing stress response and withdrawal symptoms.


Complexity of naltrexone induction is limiting broader applicability of opioid antagonist-assisted abstinence. The aim of this clinical trial was to assess the stress response to 2 low-dose naltrexone induction protocols under minimal oral sedation.

Badaras R1Jovaisa TLapinskiene IIvaskevicius J.

Read the full paper here  October 2019