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Schedule

The LDN Research Trust is proud to offer presentations introducing virtually all a practitioner would need to know about the effective use of LDN. For more extensive information on the use of LDN, be sure to register for a Full Ticket or Livestream so that you can also access our additional recorded sessions. 

2019 Schedule

9.30am

David Yeazel, MS, MPH

LDN and Education – The Key to Integration into Mainstream Medicine

David Yeazel, MS, MPH

Description

Advances in basic and clinical LDN research are expanding exponentially, yet remarkably, traditional medicine continues to be slow to incorporate LDN into traditional treatment protocols. 

Drawing upon the lessons learned from the clinical experience of a highly successful compounding pharmacy, it is clear that being fluent in the languages of research, clinical medicine, and pharmacy is critical to translate the latest findings into directly applicable clinical indication specific dosing protocols, as well as creating the guidance on expected dosing and timeframes necessary to achieve therapeutic success for the patient.

Widespread acceptance of LDN depends upon the clinician’s understanding of its proven safety and efficacy—the science continues to grow daily—what’s needed now is the development of comprehensive, standardized educational tools to provide the practitioner the knowledge and confidence to utilize LDN on behalf of their patients.

9.50am

The role of LDN in cancer management.

Prof Angus Dalgleish, MD

Description.

Analysis of available clinical data either alone or in combination with chemotherapy, and how does its known activity affecting both opiate and TLR receptors support further development.

10.10am

LDN vs. Chemotherapy: One “Unproven” Therapy Against Another?

Akbar Khan, MD

Description:

This lecture will describe some of the clinical trial evidence supporting well-accepted chemotherapy regimens for advanced cancers in adults, as well as some of the published human research about LDN. The audience will be challenged to decide if the “standard proven” therapies are actually better than LDN, which is still considered “unproven” by mainstream medicine.

10.30am

Using LDN to Quell the Over-Reactive Autoimmune Conditions Triggered by Many of Today's Cancer Drugs

Nasha Winters, ND

Description: 
In the dawning of the immunotherapies era, nearly 80% of patients undergoing these treatments will experience adverse events.  Understanding what is happening to the immune system when met with these medications and then knowing what to do to lower risk and negative outcomes with LDN will be discussed

10.50am

11.10am

Infections in Cancer and Autoimmune Disorders

Armin Schwarzbach PhD, MD

Little is known about cancer and degenerative diseases in correlation with multiple infections with viruses and bacteria. There is more known about single infections with Coxiella burnetii or Epstein Barr Virus in Non Hodgkin Lymphoma, but nothing is known about the possibility of combined multiple infections in cancer.

 

2.30pm

Traumatic Brain Injury: Low Dose Naltrexone and Microglial Modification

Sarah Zielsdorf, MD, MS

Description: 

Traumatic Brain Injury (TBI) is defined as an alteration of brain function or other evidence of brain pathology, which is attributed to an external mechanical force. This emerging epidemic targets the predominately male, able-bodied workforce, and will become one of the leading causes of death in the next decade. TBI affects every aspect of an individual. Leaky gut equals leaky brain. After brain injury, tight junctions connecting the mucosal epithelial cells become dysfunctional and allow large macromolecules (food antigens) to cross into the bloodstream, which activate the immune system. The mucosal lining often atrophies and dies with changes occurring within minutes after brain injury. Similarly, tight junctions of the blood-brain barrier (BBB) also break down, and neuroinflammatory chemicals enter and wreck havoc. Brain injury often contributes to over or under-activation of the immune system, which may lead to autoimmunity or immune compromise. TBI can trigger autonomic dysfunction, disorders of visceral sensing and processing, and impair gut motility. As the macrophages of the central nervous system (CNS), microglia are the first line of defense of the immune system. In response to TBI, microglia migrate to site of injury and eliminate cellular/molecular debris. Activated microglia release noxious chemicals including pro-inflammatory cytokines, reactive oxygen species (ROS) and nitrogen species, and cause persistent neuro-excitation via glutamate release, which exacerbates existing damage and precedes neurodegeneration. The role of microglia activation in TBI is more highly nuanced than previously described, in which microglia are activated in different phenotypes. These correspond to neurotoxic or neuroprotective priming states. Low Dose Naltrexone (LDN) is a powerful microglial modifier and use in TBI may help prevent neurodegeneration and immune dysfunction. The mechanism is LDN’s antagonist effect on non-opioid receptors (Toll-Like Receptor 4, TLR4), found on macrophages including microglial cells.

2.50pm

Treating Psychiatric Disorders with LDN Case Studies:Trauma-stress disorder, dissociative disorder, anxiety, phobia, pain and hypervigilance

Galyn Forster, MS, LPC

Medical research has recently been bringing into question the safety and effectiveness of many of our most popular pharmaceutical treatments for mental health issues. With its extremely low risk-profile, its ability to treat autoimmune and mental health issues simultaneously with only transient side effects, LDN offers an attractive, inexpensive, non-addictive, alternative.

3.10pm

Naltrexone Dosing in Traumatic Stress and Dissociative Symptoms

Ulrich Lanius, PhD

Dosing of opioid antagonists for traumatic stress syndromes and dissociative symptoms is discussed. Case studies are used to illustrate the need for different dosing and how this relates to minimizing adverse effects and maximizing beneficial effects. A neurobiological rationale for adverse effects on emotional functioning in these cases is provided, as well as specific strategies how to address such issues. Moreover, different dosing strategies and their integration with psychotherapeutic interventions are discussed.

3.30pm

3.50pm

Treatment of Chronic Pain in a Free Clinic Setting

Jill Cottel, MD

Description:

Caring for patients with chronic pain in a free clinic setting presents its own unique set of challenges.  Patients often wait until later in the presentation of their illness to seek care.  Obstacles to care can include language barriers, literacy and educational issues, and lack of consistency with health care services.  Medication options can be limited due to cost and availability, and patient compliance with the available medications is variable.  Patients have limited financial resources and struggle with basic needs such as food, clothing, transportation and housing.  Many patients have had traumatic life events, and therefore are dealing with emotional and mental health issues as well.  

Low dose naltrexone (LDN) has consistently been demonstrated to be helpful in the treatment of chronic pain from a wide variety of causes.  Despite the high prevalence of chronic pain in free clinic patients, the use of LDN has not been common due to issues with cost, availability, and lack of familiarity with the treatment.  In this presentation we look at a case series of patients receiving care at a free clinic in the Commonwealth of Virginia, who have been prescribed LDN for chronic pain.  

4.10pm

LDN Use in Women's Health

Olga Cortez, MD

Description: 

How LDN can be used to treat various gynecologic conditions

9.50am

Turning down the volume on fibromyalgia pain

Ginevra Liptan MD

Description:

Fibromyalgia is a common condition of widespread pain reflecting central nervous system sensitization. Fibromyalgia pain is notoriously resistant to standard treatments, in part because they do not address the key contribution of the glial cells, the support and immune cells that surround neurons. Central sensitization is a complex process resulting in abnormal glial cell activation and inflammation.

Low-dose naltrexone (LDN) calms activated glial cells and lowers the volume of pain transmitted to the brain. Stanford University researchers found in two separate studies that LDN substantially reduced fibromyalgia pain. Clinical experience supports these research findings, and the presentation will briefly review 4 years of data from use of LDN in a fibromyalgia specialty practice and methods to avoid interactions with opiate-based pain medications.

10.10am

Getting the most of LDN treatment and Beyond LDN

Yoon Hang "John" Kim, MD

LDN therapy has become more accepted in medicine.  However, many practitioners of LDN therapy operate from the conventional wisdom of LDN for autoimmune disorders using 1.5 mg to 4.5 mg.  However, the original article interviewing Dr. Bihari focus on LDN as an agent that can normalize immune system.  Recent articles point to the mechanism by which normalizing immune system including modulation of glial cell function via Toll like receptor 4 (TLR4).  Understanding the mechanism of TLR4 opens up whole new clinical implications not considered at this time.  The clinical use for utilizing ultra low dose naltrexone or microgram dosing of naltrexone will be reviewed.  Lastly, combination therapy with other therapeutic modalities including CBD oil and acupuncture will be discussed.

10.30am

Immune Dysfunction in Post-Treatment Lyme Disease: Using Naltrexone to Balance Chronic Inflammation

Cory Tichauer ND

Description:  

Persistent symptoms associated with Lyme disease is a controversial topic with conflicting data and clinical opinion regarding the etiology of this illness.  Underlying this controversy is research showing the persistence of Borrelia despite repeated courses of antibiotics.  This data combined with the observation that there is a clear gender disparity in the development of post-treatment lyme syndrome suggests the common denominator is a maladapted immune-mediated inflammatory response.

Validation for this hyperactive immune response can be supported by numerous lab findings including elevations of C4a, CCL19, TGF-b1, IL-4, IL-6 and IL-10 with correspondingly depressed NK Cell function, TNF-alpha and IL-2 levels.  Critical to long term recovery in these patients is modulating the immune system to correct the associated inflammatory response.  By upregulating endorphins and enkaphalins in the body, Low Dose Naltrexone (LDN), acting as a non-selective opioid receptor antagonist, can inhibit proliferation of B and T lymphocytes and the corresponding immune responses. In this way, LDN can be a valuable therapeutic tool for addressing chronic inflammation secondary to persistent Borreliosis. 

10.50am

11.10am

CBD and LDN, Can they be used together?

Prof Angus Dalgleish, MD

Description.

Review of MOA alone and together, what are the areas of potential synergy or competition?

1.50pm

The Use of LDN and Amino Acids in Parkinson's Disease

Ted Cole, DO

Description:

Presented is a novel way of addressing relative nutritional deficiencies and inflammation in Parkinson's Disease which can reverse all symptoms related to these issues.

2.10pm

LDN, Endosomes, and the Nanophysiology of Autoimmune Movement Disorders

Mark Cooper, PhD

Description:

To discuss the actions LDN, combined with other therapies, to treat autoimmune movement disorders. 

2.30pm

LDN and Memory Loss

Pamela Smith, MD

All forms of memory loss are inflammatory. This interactive seminar will focus on selected etiologies of memory loss that are inflammatory and investigate how low-dose naltrexone may be an effective therapy.

2.50pm

3.10pm

Intermittent fasting: The most natural strategy yet for fighting aging and autoimmunity?

Jill Brook MA

It has long been known that fasting can reduce inflammation and autoimmunity, and may extend life, however this strategy isn’t considered widely practical and has safety concerns. 

3.50pm

Pediatric's and LDN

Paul Anderson, NMD

The unique and special applications and dosing of LDN in the pediatric population 

4.10pm

Low Dose Naltrexone - Key Ingredient in the biomedical Treatment of Autism Spectrum Disorder

Brian Udell MD

Description

Treatment helps mitigate activation protocols that create speech pathways, decreases disruptive behaviors, and improves immune function

5.30pm - 6.30pm

9.10am

Graves Disease

Sarah Zielsdorf, MD, MS

Description: 

Graves Disease, eponym of Robert James Graves, MD,  (1835), is an autoimmune condition fraught with misunderstanding, misdiagnosis and mistreatment by the medical community. Graves’ Disease is characterized by hyperthyroidism secondary to circulating autoantibodies in which Thyroid-Stimulating Immunoglobulins (TSIs) bind to and activate thyrotropin receptors (TSH receptors), causing thyroid enlargement with subsequent thyroid hormone over-synthesis.  

Graves’ Disease may present as hyperthyroidism alone (toxic diffuse goiter), or a patient may swing hyper or hypothyroid due to concomitant Hashimoto’s Disease (characterized by the production of Thyroid Peroxidase and/or Thyroglobulin antibodies). A patient may have Hashimoto’s alone (causing hyper/hypothyroid swings) or a single thyrotoxic nodule producing thyroid hormone.

In some patients, Graves’ disease is only one of a related group of existing autoimmune conditions, which leads to dysfunction of multiple organs (i.e. polyglandular autoimmune syndromes). Graves’ and Hashimotos (representing a spectrum of autoimmune thyroid disease) are associated with Celiac disease, vitiligodiabetes mellitus type 1autoimmune adrenal insufficiency (Addison’s Disease), systemic sclerosismyasthenia gravisSjögren syndromerheumatoid arthritis, and systemic lupus erythematosus

Females are more predisposed to Graves’ Disease with precipitating or causal factors including genetics, physical/emotional trauma, acute or a chronic infections, and environmental toxins/food antigens. Epstein-Barr Virus (EBV) is an example of a viral trigger via molecular mimicry. Three traditional treatments for Graves’ Disease include anti-thyroid medications, radioiodine therapy, and thyroidectomy. Our functional medicine approach has changed the paradigm of Graves’ Disease treatment to include a root cause approach of treatment. Low Dose Naltrexone (LDN) is a critical therapy in conjunction with removal of autoimmune triggers/environmental stressors, intense diet, nutritional, and lifestyle modifications, herbal therapies, and treatment of underlying causes (e.g. infections).

9.50am

LDN and Cellular Hypothyroidism: When TSH is Normal but Reverse T3 is Elevated

Carrie Jones, ND, MPH

Hypothyroidism is well understood in conventional medicine as an elevated TSH along with associated symptoms. Unfortunately, TSH is determine by the levels of T3 in the pituitary as determined by the type 2 deiodinase. In the periphery, type 1 deiodinase is what converts T4 into T3 while type 3 deiodinase converts T4 into reverse T3. Understanding what might cause a decrease in either type 1 or type 2 or an increase in type 3 deiodinase coupled with low dose naltrexone treatment could greatly improve lab and symptom outcomes in patients with hypothyroidism or for those who experience classical hypothyroid symptoms but have a TSH within range on a lab report.

10.10am

The role LDN plays in the body's hormonal symphony: how a well-conducted orchestra enhances the efficacy of LDN.

Harpal Bains MD

Description: 

Like a symphony orchestra, the human body works best when all of its instruments are in tune and playing together. 

 

However, without an experienced conductor the orchestra will fall out of harmony, as will the human body without holistic management of the endocrine systems.

It is perhaps too easy for practitioners to forget this by focussing mostly, or only, on the most pressing issue a patient has. For example, focussing only on improving thyroid function for a thyroid patient, but ignoring the rest of the body.

When we take a step and manage the body as a whole, conducting the orchestra rather than just the soloists, the effects have the potential to make a huge difference to every system in the body.

In our orchestra, Low Dose Naltrexone is the wonderful soloist who can raise the symphony to another level. But the soloists always requires the full support of the whole stage. 

This presentation aims to demonstrate the importance of this concept of total management with specialist supporting acts.

10.30am

The Gut-Thyroid Connection, Profound but Under Appreciated

Michael Ruscio, MD

  • Description (300 word max)

    • The gastrointestinal tract markedly influences thyroid via autoimmunity, thyroid hormone conversion and absorption of thyroid medication.  Mismanagement of digestive health is one of the most common reason for recalcitrant ‘thyroid symptoms’ according to Dr. Ruscio’s observations. 
    • The talk will highlight the clinically relevant actions that can be taken to improve thyroid health via optimization of the GI tract. 

10.50am

11.10am

Patient selection and inflammation.

Dana Keaton ND

Description:

Many illnesses are amenable to LDN treatment. Looking at LDN as an inflammation intervention widens the scope of which patients may benefit.

11.30am

Autoimmune Hepatitis

Paul Battle, PA-C

Description

Current treatments 

Ramifications of hepatitis 

Case presentation 

1.15pm - 2.00pm

A Pharmacist's Perspective on Comprehensive Immune Health Consultations and Applications of LDN

Amy Lamb Pharm

This session will review the interactions and assessments in a community pharmacy practice that result in recommendations for LDN therapy initiation. The session will also review complementary therapies for patients seeking functional improvement of immune dysregulation

Alternative strategies for alleviating fibromyalgia pain: Tips, tricks and case studies from a specialty practice

Ginevra Liptan MD

Description:

Fibromyalgia is a common condition of widespread pain reflecting central nervous system sensitization. To understand how to direct treatment of this complex illness one needs to understand the pathophysiology leading to abnormal spinal cord amplification of pain signals, so will start with a brief tour of our scientific understanding of fibromyalgia. With this data it will be clear why fibromyalgia pain has been notoriously resistant to standard treatments.

Fortunately there are some newer alternative pain relief treatments that specifically target the central nervous system sensitization. One of the best studied is low-dose naltrexone (LDN) which calms activated glial cells and lowers the volume of pain transmitted to the brain.

Several case studies of fibromyalgia patients using LDN in a specialty practice will be reviewed, each highlighting one important aspect of prescribing LDN for this specific population. One challenge to prescribing LDN to patients with fibromyalgia is that many utilize opiate-based medications to manage their symptoms. There are ways to overcome this, including using ultra low-dose naltrexone along with separating dosage times adequately to lessen any interactions.

Case Studies from a Women's Health Naturopathic Practice

Tracy Magerus, ND

Many general practitioners may feel intimidated to include LDN into their regular patient care.Dr. Mageruswill present 6 cases from her practice where she has successfully used LDN as an adjunctive therapy to treat infertility, lupus, endometriosis, multiple sclerosis and hashimoto's thyroiditis.

Client Attraction Secrets: Become a Sought After Expert With a Full Practice of Ideal, Committed Clients (Regardless of Insurance

Lesli Bitel, MBA, RDN, LDN

Where to focus your marketing muscle that will skyrocket your inquiries...even  though it seems counter-intuitive

Compounding 101: The Basics of Compounding with Naltrexone

Tara Thompson, PharmD

There is much more to compounding pharmacy than mixing ingredients. This presentation will give a glimpse into the world of compounding pharmacy, the regulations and guidelines that we strive to meet, how to choose a compounding pharmacy, and how to writefor a low dose naltrexone compounded prescription. Specifically, different bases and equipment used in the compounding of low dose naltrexone will be discussed and how to choose the right dosage form for your unique patient. 

Expansion on Intermittent Fasting

Jill Brook MA

Expansion on the Live Presentation: Intermittent fasting: The most natural strategy yet for fighting aging and autoimmunity?

Extension on Parkinson's Disease

Ted Cole, DO

30 minute extension on Parkinson's Disease Live Presentation

Extension to LDN and Cellular Hypothyroidism

Carrie Jones, ND, MPH

30 minute extension to LDN and Cellular Hypothyroidism Live Presentation

Extension to Patient selection and inflammation

Dana Keaton ND

30 minute extension to Patient selection and inflammation Live Presentation

Extension to Treating Depression in Patients with Autoimmune Conditions

Mark Shukhman, MD

30 minute extension to Treating Depression in Patients with Autoimmune Conditions LIve Presentation

Extension to Treating Psychiatric Disorders with LDN

Galyn Forster, MS, LPC

30 minute extension to Treating Psychiatric Disorders with LDN Live Presentation.

Extension: Infections in Cancer and Autoimmune Disorders

Armin Schwarzbach PhD, MD

30 minitue extension on Infections in Cancer and Autoimmune Disorders Live Presentation

LDN and integrative treatment of Fibromyalgia, Inflammatory Disease, and Headache

Andrew David Shiller MD

Description: 

LDN is a potent immune modulator and analgesic, that has synergy with other aspects of an integrative approach to healing pain and inflammatory conditions

LDN and vulvodynia

Debbie Rice ND

Description:

This lecture attempts further understanding with regard to the mechanism of pain and discomfort associated with vulvodynia and understanding different treatment options to create improved quality of life for those suffering with vulvodynia.

LDN for Opthalmic use

Andy Stein, Pharm

Discussion on the clinical use of naltrexone for ophthalmic pain.

Elliot Udell, DPM

Low Dosage Naltrexone In The Management of Pedal Neuropathic Pain

Elliot Udell, DPM

Description:

To show the audience how the use of LDN has been used to manage neuropathic pedal disorders. 

Low Dose Naltrexone treatment for Premenstrual Syndrome - PMS

Phil Boyle, GP

Description

Outline the problem of PMS, current treatments and new treatment with LDN

Making a difference

Michelle Moser, Pharm

Description

The impact of a Pharmacist in the LDN  triangle

Ocular Uses for Naltrexone

Amber Myers PharmD

Description: 

Naltrexone is used for many areas of the body. But what about the eyes? This presentation will shed light on the use of Naltrexone for ocular issues from a pharmacist’s perspective, as well as considerations for ocular naltrexone formulations. 

Safety and Quality in Low-Dose Naltrexone Compounding

James Iversen

Description: 

This session will discuss compounding techniques and quality control procedures used in the process of compounding low dose naltrexone. The topics discussed will apply to compounding of capsules, oral solutions, and topical LDN preparations. 

The Art of LDN Prescribing In Hashimoto’s thyroiditis

Igor Schwartzman ND

Hashimoto's thyroiditis (autoimmune thyroiditis) is the most common cause of hypothyroidism in the United States. It is characterized clinically by a gradual decline in thyroid function due to the immune-mediated destruction of the gland tissue. Hashimoto’s thyroiditis is an inflammatory process, and since low dose naltrexone (LDN) appears to act as an immunomodulator it is can be an excellent adjunct therapy in clinical practice. Additionally, LDN use in patients with Hashimoto’s not only helps reduce a myriad of thyroid-associated symptoms, but can also lead to a reduced thyroid replacement dosing. Many people with Hashimoto’s often exhibit numerous sensitivities and aggravations to different therapies.

Debbie Hamilton, MD

The latest research on Th17 and its role in autoimmunity

Debbie Hamilton, MD, MPH

Description: The old paradigm that immune balance is obtained by regulating T helper1 (Th1)and T helper 2 (Th2) cells has been challenged along with the idea that elevated Th1 is always associated with autoimmune disease. With the differentiation of T helper 17 (Th17) cells from Th1 cells came the realization that the immune system is much more complex than the Th1/Th2 paradigm. Decreasing autoimmunity and chronic infections involves balancing Th17 and Treg cells in addition to Th1 and Th2 cells.  Understanding the imbalanced immune cycle that is common in many of our chronic disease patients leads to new treatment modalities including transfer factors, natural anti-inflammatories, and LDN.

Dr Scott Zashin

Treatment of Sjogren's Syndrome with LDN

Scott Zashin MD

Description

Sjogren's Syndrome is a chronic autoimmune inflammatory disorder characterized by inflammation in the tear ducts and salivary glands causing both dryness of the eyes and mouth. In addition, chronic fatigue as well as muscle and joint pain are common features. In addition to its pain relieving properties, LDN is also  has anti inflammatory benefits based on its inhibition of toll like receptors. As a result, it may be an excellent treatment for this condition which is limited by the lack of FDA approved therapies. In this session, I will present a case report of a patient with Sjogren's Syndrome who had not responded to standard treatment but had a dramatic and rapid improvement with LDN.

Using Low Dose Naltrexone To Help SIBO Patients

Mona Morstein ND

SIBO, small intestine bacterial overgrowth, is estimated to account for up to 60% of all IBS patients.  That’s millions of patients.  The core etiology of developing SIBO is due to auto-immune damage to the nerves that stimulate the muscles of the small gut to move contents forward.  As a result, the colon backwashes bacteria/archae into the small gut and they proliferate, causing significant symptoms and damage to the small gut lining.   Low Dose Naltrexone can be an invaluable tool in working with SIBO patients.  It can help reduce the auto-immunity and acts as a gentle prokinetic, helping to move contents forward to prevent SIBO recurrence.  Learn about SIBO, auto-immunity, prokinetics at this interesting lecture by a SIBO expert." 

What Patients Need to Know About Telemedicine

Sajad Zalzala, MD

Description:

Discussing the rules, regulations, uses, restrictions, pros/cons of consulting with a health care provider by electronic means (phone, video, web chat, etc...)