Skip to main content

Mast cell activation syndrome and potential role for LDN


Leonard Weinstock, MD


Mast cell activation syndrome (MCAS) is a common, yet rarely recognized, chronic multi-system disease with abnormal mast cell (MC) function producing predominantly inflammatory and allergic illness. Gastrointestinal manifestations of MCAS are common. Untreated MCAS can be the explanation for refractory and vexing disorders. The symptoms of MCAS are numerous and affect multiple organs and systems, which further complicates the clinical presentation. MCAS has been estimated to have prevalence of 1%-17% yet is often not considered in differential diagnoses. MCAS is associated with a number of other idiopathic disorders, including hypermobile Ehlers-Danlos syndrome (hEDS) and dysautonomia such as postural orthostatic tachycardia syndrome (POTS). Pain in the muscles, joints, bladder and GI tract are common symptoms in MCAS. These symptoms along with fatigue are potential areas where LDN can help patients.

Session Learning Objective:

  • Obtain a general understanding of MCAS.
  • Understand how chemical mediators can cause pain.
  • Learn how LDN can reduce pain in this situation.

Session Outline:

  • Review the MCAS disorder.
  • Review a case series of MCAS patients who have been treated with LDN by Dr. Weinstock.