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LDN and CRPS

Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN) – Pradeep Chopra & Mark S. Coope

  1. Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN) – Pradeep Chopra & Mark S. Coope

Published in the Journal of Neuroimmune Pharmacology

http://www.ldnresearchtrustfiles.co.uk/docs/Treatment%20of%20CRPS%20with...

The PDF to download 

J Neuroimmune Pharmacol. 2013 Apr 2. [Epub ahead of print]

Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN).

Chopra P, Cooper MS.

Source

Department of Medicine, Alpert Medical School of Brown University, 102 Smithfield Ave, Pawtucket, RI, 02860, USA, painri@yahoo.com.

Abstract

Complex Regional Pain Syndrome (CRPS) is a neuropathic pain syndrome, which involves glial activation and central sensitization in the central nervous system. Here, we describe positive outcomes of two CRPS patients, after they were treated with low-dose naltrexone (a glial attenuator), in combination with other CRPS therapies. Prominent CRPS symptoms remitted in these two patients, including dystonic spasms and fixed dystonia (respectively), following treatment with low-dose naltrexone (LDN). LDN, which is known to antagonize the Toll-like Receptor 4 pathway and attenuate activated microglia, was utilized in these patients after conventional CRPS pharmacotherapy failed to suppress their recalcitrant CRPS symptoms.

PMID:

23546884

[PubMed - as supplied by publisher]

2. CRPS/RSD: Updates on treatment - Complex Regional Pain Syndrome or Reflex  Sympathetic Dystrophy

Pradeep Chopra, MD - Assistant Professor (Clinical) Brown Medical School Director, Pain Management Center, RI 

3. LDN and Chronic Pain - Dr Pradeep Chopra - Pain Specialist - Newsletter Article

4. LDN in pain management - Dr Samyadev Datta, Pain Specialist - Newsletter Article

5. LDN in the treatment of pain - Dr Jan M. Keppel Hesselink - Pain Specialist